The theoretical basis of reservoir pressure in arteries
arxiv(2024)
摘要
The separation of measured arterial pressure into a reservoir pressure and an
excess pressure was introduced nearly 20 years ago as an heuristic hypothesis.
We demonstrate that a two-time asymptotic analysis of the 1-D conservation
equations in each artery coupled with the separation of the smaller arteries
into inviscid and resistance arteries, based on their resistance coefficients,
results, for the first time, in a formal derivation of the reservoir pressure.
The key to the two-time analysis is the existence of a fast time associated
with the propagation of waves through the arteries and a slow time associated
with the convective velocity of the blood. The ratio between these two time
scales is given by the Mach number; the ratio of a characteristic convective
velocity to a characteristic wave speed. If the Mach number is small, a formal
asymptotic analysis can be carried out which is accurate to the order of the
square of the Mach number. The slow-time conservation equations involve a
resistance coefficient that models the effect of viscosity on the convective
velocity. On the basis of this resistance coefficient, we separate the arteries
into the larger inviscid arteries where the coefficient is negligible and the
smaller resistance arteries where it it is not negligible. The slow time
pressure in the inviscid arteries is shown to be spatially uniform but varying
in time. We define this pressure as the reservoir pressure. Dynamic analysis
using mass conservation in the inviscid arteries shows that the reservoir
pressure accounts for the storage of potential energy by the distension of the
elastic inviscid arteries during early systole and its release during late
systole and diastole. This analysis thus provides a formal derivation of the
reservoir pressure and its physical meaning.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要