The Abnormal Signaling of the B Cell Receptor and Coreceptors of Lupus B Cells

It is easily understood that studying the physiology and pathophysiology of the BCRtriggered cascade is of importance, particularly in such diseases as systemic lupus erythematosus (SLE) that are considered by many as a “B cell disease”. Even though B cells are not considered as the only players in lupus pathogenesis, and other immune and non-immune cells are certainly involved, it is the success of recent B celltargeting treatment strategies that ascribe a critical role to the lupus B cell.