PD47-04 STONE (STENT OR NEPHROSTOMY) STUDY

You have accessJournal of UrologyStone Disease: Surgical Therapy (Including ESWL) IV (PD47)1 May 2024PD47-04 STONE (STENT OR NEPHROSTOMY) STUDY Nora Hendriks, Hugo W. Schuil, Guido M. Kamphuis, Bart C. H. Oskam, Tom J. H. Arends, Diederick Duijvesz, Bart van der Heij, Irene Tjiam, Wout Scheepens, Frank C. H. d'Ancona, Janneke I. M. van Uhm, Herman van Roijen, Saskia Weltings, Rutger W. van der Meer, Judith E. Bosmans, Rob C. M. Pelger, Harrie P. Beerlage, Ruben G. Duijnhoven, and Barbara M. A. Schout Nora HendriksNora Hendriks , Hugo W. SchuilHugo W. Schuil , Guido M. KamphuisGuido M. Kamphuis , Bart C. H. OskamBart C. H. Oskam , Tom J. H. ArendsTom J. H. Arends , Diederick DuijveszDiederick Duijvesz , Bart van der HeijBart van der Heij , Irene TjiamIrene Tjiam , Wout ScheepensWout Scheepens , Frank C. H. d'AnconaFrank C. H. d'Ancona , Janneke I. M. van UhmJanneke I. M. van Uhm , Herman van RoijenHerman van Roijen , Saskia WeltingsSaskia Weltings , Rutger W. van der MeerRutger W. van der Meer , Judith E. BosmansJudith E. Bosmans , Rob C. M. PelgerRob C. M. Pelger , Harrie P. BeerlageHarrie P. Beerlage , Ruben G. DuijnhovenRuben G. Duijnhoven , and Barbara M. A. SchoutBarbara M. A. Schout View All Author Informationhttps://doi.org/10.1097/01.JU.0001008652.62443.0a.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Obstruction by urolithiasis can result in renal colic, renal impairment and infection with possible sepsis and concurrent need for drainage. Since direct stone removal is not always a feasible option, acute interventions such as a percutaneous nephrostomy (PCN) or an internal stent, are widely applied. Globally, guidelines underline the lack of evidence of comparative effectiveness between these interventions. The objective of this study is to investigate whether an internal stent is non-inferior to a PCN in patients with obstructive urolithiasis with regards to effectiveness, patient reported outcome measures (PROMS) and costs. METHODS: In this randomized controlled trial performed in 11 hospitals in the Netherlands, 177 patients with an indication for drainage (infection, pain, renal impairment) were randomized for either PCN or internal stent. Clinical outcomes and PROMS were collected until 3 months after intervention. The primary outcome was time to recovery. RESULTS: To date, 177 patients completed this study. Baseline characteristics were comparable (Table 1). The indication for intervention was infection in 36.7% (N=65), pain in 73.4% (N=130) and deterioration of kidney function in 63.3% (N=112) of patients. Time to recovery was similar between internal stent (median 1.0 (0-32) days; 95% CI 1.0-1.0) and PCN (median 1.0 (0-11) days; 95% CI 1.0-1.0). Adverse events, (including irritative bladder symptoms and mild pain) were comparable between both groups (internal stent 38.8%; PCN 38.0% p=1.000). CONCLUSIONS: Based on the preliminary results of this RCT an internal stent is equally as effective as a PCN concerning time to recovery. Therefor decision of treatment method can be based on other outcomes such as PROMS and costs which are included in the STONE study. Download PPT Source of Funding: Zon MW © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e981 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Nora Hendriks More articles by this author Hugo W. Schuil More articles by this author Guido M. Kamphuis More articles by this author Bart C. H. Oskam More articles by this author Tom J. H. Arends More articles by this author Diederick Duijvesz More articles by this author Bart van der Heij More articles by this author Irene Tjiam More articles by this author Wout Scheepens More articles by this author Frank C. H. d'Ancona More articles by this author Janneke I. M. van Uhm More articles by this author Herman van Roijen More articles by this author Saskia Weltings More articles by this author Rutger W. van der Meer More articles by this author Judith E. Bosmans More articles by this author Rob C. M. Pelger More articles by this author Harrie P. Beerlage More articles by this author Ruben G. Duijnhoven More articles by this author Barbara M. A. Schout More articles by this author Expand All Advertisement PDF downloadLoading ...