MP68-03 RACE HAS NO IMPACT ON PROSTATE CANCER-SPECIFIC MORTALITY, WHEN COMPARING PATIENT WITH SIMILAR OVERALL HEALTH STATUS: AN ANALYSIS OF POPULATION-BASED COHORT

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History II (MP68)1 May 2024MP68-03 RACE HAS NO IMPACT ON PROSTATE CANCER-SPECIFIC MORTALITY, WHEN COMPARING PATIENT WITH SIMILAR OVERALL HEALTH STATUS: AN ANALYSIS OF POPULATION-BASED COHORT Shane Tinsley, Marco Finati, Alex Stephens, Giuseppe Chiarelli, Giuseppe O. Cirulli, Eric Williams, Yuzhi Wang, Akshay Sood, Nicolò Buffi, Giovanni Lughezzani, Carlo Bettocchi, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Giuseppe Carrieri, Craig Rogers, and Firas Abdollah Shane TinsleyShane Tinsley , Marco FinatiMarco Finati , Alex StephensAlex Stephens , Giuseppe ChiarelliGiuseppe Chiarelli , Giuseppe O. CirulliGiuseppe O. Cirulli , Eric WilliamsEric Williams , Yuzhi WangYuzhi Wang , Akshay SoodAkshay Sood , Nicolò BuffiNicolò Buffi , Giovanni LughezzaniGiovanni Lughezzani , Carlo BettocchiCarlo Bettocchi , Andrea SaloniaAndrea Salonia , Alberto BrigantiAlberto Briganti , Francesco MontorsiFrancesco Montorsi , Giuseppe CarrieriGiuseppe Carrieri , Craig RogersCraig Rogers , and Firas AbdollahFiras Abdollah View All Author Informationhttps://doi.org/10.1097/01.JU.0001008744.60568.e8.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Non-Hispanic Black (NHB) patients are twice as likely to succumb to prostate cancer (PCa), when compared to non-Hispanic White (NHW) patients. This might stem, at least partially, from an unequal access to healthcare, and results in NHB patients having a shorter life expectancy than their NHW counterparts. To mitigate these biases, which probably originate from systemic racism, we sought to compare prostate cancer-specific mortality (PCSM) in NHB vs. NHW men matched based on their calculated other-cause mortality (OCM) risk. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify NHB men and NHW men who were diagnosed with PCa between 2004 to 2009. This time period was selected to obtain a sufficient long-term follow-up. A Cox regression model was used to calculate the 10-year OCM risk using all available covariates. This calculated risk was used to construct a 1:1 propensity score matched (PSM) cohort of NHB and NHW patients. Then, a competing risk multivariate model tested the impact of self-identified race (NHB vs. NHW) on PCSM, after accounting for all available covariates. RESULTS: There was a total of 93,957 patients included in our final cohort, with 19,286 (20.6%) being NHB men and 74,571 (79.4%) being NHW men. The median (IQR) follow-up was 11.2 years (9.8-12.7). In the unmatched cohort, 10-year PCSM and OCM were 5.3% vs. 3.4% and 13.7% vs. 8.4% in NHB vs. NHW patients (all p-value <0.0001). The standard mean difference was <0.1 for all variables included in the PSM model, which included a good match. In the matched cohort, 10-year OCM was 16.8% and 13.5% in NHB vs. NHW (p-value <0.0001), while the 10-year PCSM was 5.9% vs. 5.7% (p-value = 0.2). On multivariate analysis, in the matched PCSM cohort, NHW men had a hazard ratio of 0.99 (95% CI: 0.89-1.09) compared to NHB men with a p-value of 0.8. CONCLUSIONS: Our results showed similar PCSM in NHB and NHW patients, when matched based on their calculated 10-year OCM risk. Our report is the first to indicate at a population-based level that after alleviating the known systematic biases against NHB men in the "real world". Download PPT Source of Funding: We would like to acknowledge the VUI Center of Outcomes Research, Analytics and Evaluation fund supported by the Vattikuti Foundation and the Menon Foundation © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1108 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Shane Tinsley More articles by this author Marco Finati More articles by this author Alex Stephens More articles by this author Giuseppe Chiarelli More articles by this author Giuseppe O. Cirulli More articles by this author Eric Williams More articles by this author Yuzhi Wang More articles by this author Akshay Sood More articles by this author Nicolò Buffi More articles by this author Giovanni Lughezzani More articles by this author Carlo Bettocchi More articles by this author Andrea Salonia More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Giuseppe Carrieri More articles by this author Craig Rogers More articles by this author Firas Abdollah More articles by this author Expand All Advertisement PDF downloadLoading ...