PD19-09 ARE THERE DIFFERENCES IN MRI FINDINGS BETWEEN CRIBRIFORM AND NON-CRIBRIFORM CANCER? AN ANALYSIS USING RADIOMICS AND DELTA-RADIOMICS

You have accessJournal of UrologyProstate Cancer: Detection & Screening II (PD19)1 May 2024PD19-09 ARE THERE DIFFERENCES IN MRI FINDINGS BETWEEN CRIBRIFORM AND NON-CRIBRIFORM CANCER? AN ANALYSIS USING RADIOMICS AND DELTA-RADIOMICS Koki Enomoto, Soichiro Yoshida, Haruto Izumi, Sho Uehara, Yoh Matsuoka, Kohei Yamamoto, Daisuke Hirahara, Tatsunori Saho, Eichi Takaya, Shohei Fukuda, Yuma Waseda, Hajime Tanaka, Kenichi Ohashi, and Yasuhisa Fujii Koki EnomotoKoki Enomoto , Soichiro YoshidaSoichiro Yoshida , Haruto IzumiHaruto Izumi , Sho UeharaSho Uehara , Yoh MatsuokaYoh Matsuoka , Kohei YamamotoKohei Yamamoto , Daisuke HiraharaDaisuke Hirahara , Tatsunori SahoTatsunori Saho , Eichi TakayaEichi Takaya , Shohei FukudaShohei Fukuda , Yuma WasedaYuma Waseda , Hajime TanakaHajime Tanaka , Kenichi OhashiKenichi Ohashi , and Yasuhisa FujiiYasuhisa Fujii View All Author Informationhttps://doi.org/10.1097/01.JU.0001009448.41537.64.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Cribriform cancer (CC) is an aggressive subtype of prostate cancer, and CC is considered difficult to identify by subjective assessment of multiparametric MRI (mpMRI). However, MRI texture features of CC have not been fully investigated. Delta-radiomics is a new method of analyzing changes in texture features that are comprehensively evaluated by radiomics. The aim of this study is to evaluate the differences in mpMRI findings between CC and non-CC using radiomics and delt-radiomics, along with subjective assessment. METHODS: Of the prostate cancer patients who underwent radical prostatectomy (RP) between 2017 and 2021, we analyzed consecutive 103 who underwent mpMRI preoperatively. The presence of CC within the largest cancer lesion were examined on RP specimens. MRI findings of lesions≥5 mm in diameter with CC foci (CCL) were compared with those of significant cancer lesions (Gleason grade group (GG)≥2)≥5 mm without CC foci (non-CCL). Texture features of T2-weighted images (T2WI), diffusion-weighted images (DWI), and fat-suppressed T1-weighted images (T1WI) before and around 34 secs after contrast administration were extracted by radiomics analysis. Pre- and post-contrast changes of texture features in T1WI were evaluated using delta-radiomics. Radiomics analysis was performed using imaging software, LIFEx to extract 32 second-order texture features. RESULTS: Forty-three patients had CC. Of the 25 CCLs (median diameter: 15 mm, GG 2/3/4/5: 5/13/6/1), 14 CCLs were identified by mpMRI (PI-RADS 3/4/5: 1/3/10). The remaining 60 patients had non-CC. Of the 45 non-CCLs (median diameter: 16 mm, GG 2/3/4/5: 32/9/2/2), 27 non-CCLs were identified by mpMRI (PIRADS 3/4/5: 7/8/12); there was no significant difference in PI-RADS scores between CCL and non-CCL. Radiomics analysis showed a significant difference in only GLCM-Correlation on T2WI (p=0.0077), and no significant difference in any of the texture features on DWI. There was no significant difference between CCL and non-CCL in the pre- and post-contrast changes on T1WI in texture features. CONCLUSIONS: The only difference between CCL and non-CCL in the subjective evaluation and in the texture features in mpMRI was the GLCM-Correlation of T2WI. The mpMRI findings of CCL and non-CCL are considered to be almost identical. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e443 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Koki Enomoto More articles by this author Soichiro Yoshida More articles by this author Haruto Izumi More articles by this author Sho Uehara More articles by this author Yoh Matsuoka More articles by this author Kohei Yamamoto More articles by this author Daisuke Hirahara More articles by this author Tatsunori Saho More articles by this author Eichi Takaya More articles by this author Shohei Fukuda More articles by this author Yuma Waseda More articles by this author Hajime Tanaka More articles by this author Kenichi Ohashi More articles by this author Yasuhisa Fujii More articles by this author Expand All Advertisement PDF downloadLoading ...