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Bidirectional Modulation of TCA Cycle Metabolites and Anaplerosis by Metformin and Its Combination with SGLT2i

Makoto Harada,Jonathan Adam,Marcela Covic,Jianhong Ge,Stefan Brandmaier,Caroline Muschet,Jialing Huang,Siyu Han, Martina Rommel,Markus Rotter,Margit Heier,Robert P. Mohney,Jan Krumsiek,Gabi Kastenmüller,Wolfgang Rathmann,Zhongmei Zou,Sven Zukunft,Markus F. Scheerer,Susanne Neschen,Jerzy Adamski,Christian Gieger,Annette Peters, Donna P. Ankerst,Thomas Meitinger,Tanya L. Alderete,Martin Hrabe de Angelis,Karsten Suhre,Rui Wang-Sattler

CARDIOVASCULAR DIABETOLOGY（2024）

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关键词
Pharmacometabolomics,Metformin,SGLT2 inhibitors,TCA cycle,Anaplerosis,Anti-inflammatory effects,Metabolic dysfunction-associated steatotic liver disease (MASLD),Type 2 diabetes
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