Review on Cerebral Malaria—pathogenesis and Role of EphA2 Receptor in Maintaining Blood Brain Barrier Integrity
Health Sciences Review（2024）
Key words
Cerebral malaria, EphA2 receptors, Ephrin A1, Blood Brain Barrier Disruption, endothelial cells apoptosis, Possible intervention, Immune cell responses, Vaccination,Cerebral malaria: It is a complex of severe hallmarks of Plasmodium species infection in the brain,EphA2 receptors: The receptors that have been connected to numerous neurological illnesses and play an important role in cerebral malaria, which is associated with a breakdown of the blood-brain barrier (BBB),Ephrin A: The primary ligand involved in EphA2 - ephrin-A interaction between cells results in cellular activities such adhesion, cellular migration, and morphological changes in cells that facilitates endothelial cells apoptosis leads to cerebral malaria,BBB Disruption: The pathological outcome of EphA2 targeting ephrin A ligand-expressing CD8+ T complex cell adhesion, which ultimately induces endothelial cell apoptosis,Childhood neurodisability: Cerebral Malaria survivors face lifelong effects and a higher incidence of childhood neurodisability,Possible intervention: Understanding cerebral malaria pathogenesis and its possible intervention may be new therapeutic strategies for treating cerebral malaria,Immune cell responses: Migration and activation of numerous immune cells towards endothelial cells causes neuroinflammatory response,Vaccination: Immunogenicity of the vaccine is the ability of the vaccine to produce an immune response whereas the efficacy is a measure of the ability of vaccine to prevent the disease
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