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Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That is Synthetically Lethal with MTAP-Deleted Cancers.

Kevin M. Cottrell,Kimberly J. Briggs,Douglas A. Whittington,Haris Jahic,Janid A. Ali,Charles B. Davis,Shanzhong Gong,Deepali Gotur,Lina Gu,Patrick McCarren,Matthew R. Tonini,Alice Tsai,Erik W. Wilker, Hongling Yuan,Minjie Zhang,Wenhai Zhang,Alan Huang,John P. Maxwell

JOURNAL OF MEDICINAL CHEMISTRY（2024）

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PRMT5
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