Assessment of Dietary Intake and its Inflammatory Potential in Persons with Pediatric-onset Multiple Sclerosis

Objective To compare diet and the modified dietary inflammatory index (mDII) between individuals with pediatric-onset multiple sclerosis (PoMS), monophasic acquired demyelinating syndromes (monoADS), and controls. Methods The association between diet, mDII, and disease status was examined in 131 individuals with PoMS/monoADS/controls (38/45/48) using logistic regression. Results The associations between diet and PoMS were modest, reaching significance for whole grain intake (adjusted odds ratio, aOR=0.964, 95% confidence intervals, CI:0.934–0.995) but not mDII (aOR=1.20, 95%CI:0.995–1.46) versus controls. No findings for monoADS reached significance versus controls. Conclusions Individuals with PoMS, but not monoADS, had lower dietary whole grain intake than controls.