Development of docetaxel-loaded (Soluplus®–PF108) mixed micelles vacuum foam-dried product for improved stability and melanoma treatment by QbD approach

Rutuja Chougale,Kiran Patil,John Disouza,Ashok Hajare,Namdeo Jadhav,Popat Kumbhar

Future Journal of Pharmaceutical Sciences（2024）

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Abstract

Docetaxel (DTX) finds extensive use in treating various cancers, but its limited solubility, side effects, and multi-drug resistance (MDR) hinder its effectiveness. To enhance DTX's properties, the study aimed to formulate DTX-loaded mixed micelles (MMs) and evaluate their anticancer potential using Quality by Design (QbD) approach. Using solvent evaporation, DTX-loaded MMs were prepared and optimized via a 32 full factorial design. The optimized formulation (R5) displayed a

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Key words

Docetaxel,Quality by design,Vacuum foam drying,Stability,Melanoma,Mixed micelles

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