WCN24-943 CASE REPORT: CHRONIC MYELOMONOCYTIC LEUKEMIA PATIENT DEVELOPED PROGRESSIVE CHRONIC KIDNEY DISEASE CAUSED BY LYSOZYME-INDUCED NEPHROPATHY
Kidney International Reports(2024)
摘要
Lysozyme-induced nephropathy is a rare kidney manifestation mostly associated with hematologic diseases, especially Chronic Myelomonocytic Leukemia (CMML). This nephropathy is rare, underrecognized and underestimated in this population. Lysozyme is a 15 kDa cationic protein, produced mainly by monocytes and macrophages. The disease pathogenesis is not well understood; however, it is probably related to lysozyme's direct tubular injury after endocytic reabsorption by proximal tubules, leading to ischemic tubular damage.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要