Immuno-persistence after the 4th and 5th Dose of Inactivated Polio Vaccines in School-Aged Children

Abstract Despite decades of research, questions remain about the persistence of neutralising antibodies (nAb) and serological correlates of polio vaccine efficacy. In a cross-sectional study among 299 children in Hong Kong, we estimated that the mean nAb titres against polioviruses type 1, 2 and 3 (PV1, PV2 and PV3) one month after receiving the 4th dose of inactivated polio vaccine (IPV) at 19 months of age were 2,068 (95% credible interval: 1,517 – 2,864), 4,705 (3,439 – 6,436) and 2,758 (1,894 – 4,086), but declined substantially in 4 years to 268 (222 – 325), 751 (630 – 900), and 411 (323 – 521), respectively. Administration of the 5th dose of IPV restored nAb titres among children aged 6-7 years, and the decline in nAb titres was slightly slower with the estimated mean titres of 355 (272 – 462), 538 (427 – 681), and 548 (378 – 786) against PV1, PV2, and PV3 at 4 years post the 5th dose. We estimated that the proportion of children who were seroprotected against PV1, PV2 and PV3 would drop below 90% at: (i) 8.2, 10.8, 8.7 years after the 4th dose; and (ii) 11.6, 11.2, 11.0 years after the 5th dose, highlighting the importance of maintaining populational immune persistence at high nAb levels.