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Development of a Novel Chemoenzymatic Process for 3-(Methylsulfonyl)-l-phenylalanine Phenylmethyl Ester─A Key Intermediate of Lifitegrast (Xiidra)

Chuanjun Wu, Heng Guo,Jiawei Tang,Lintao Xia, Jianfen Shao, Yongfu He, Fei Chen, Peng, Yuewen Han,Chuanmeng Zhao,Fuli Zhang,Shaoxin Chen

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2024）

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Lifitegrast,enzymatic resolution,phenylalaninederivatives,synthesis process
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