Influence of sample orientation on cytocompatibility of pure magnesium

This study aimed to investigate how sample orientation and texture distributions affect pure magnesium (Mg) cytocompatibility behavior and discuss the connection between metallurgical and microstructural factors with cytocompatibility. Three samples with varying orientations but the same grain size were used to investigate the influence of texture distribution on cell viability and adhesion. Results showed that an increase in the intensity of hexagonal closed-packed (hcp) basal planes or texture distribution with more basal planes improved cell viability and adhesion. Corrosion behavior and surface energy were identified as the link between microstructural factors and cytocompatibility properties. Different corrosion tests were performed to observe the enhancement of corrosion resistance whenever the texture distribution was dominated with basal planes. These findings suggest that the cytocompatibility of Mg alloys is fundamentally related to the orientation or texture distribution of the samples, with more hcp basal planes resulting in better cell viability and adhesion.