A Hydrogen-Bonded Organic Framework Equipped with a Molecular Nanovalve

The concept of a molecular nanovalve is applied to a synthesized biocompatible hydrogen-bonded organic framework (HOF), termed RSS-140, to load, trap, and subsequently release an antioxidant on command. Specifically, we exploit the pore windows of RSS-140 (i.e., beta-CD cavities) to first load and trap the antioxidant, Trolox, within the internal pores of the HOF (Trolox subset of RSS-140) and, to prevent it from leaching, utilize supramolecular chemistry to complex azobenzene (Azo) with beta-CD (Trolox subset of Azo@RSS-140). The molecular nanovalve is fully realized upon exposing Trolox subset of Azo@RSS-140 to UV light with a specific wavelength, which induces Azo isomerization, Azo decomplexation from beta-CD, and subsequent release of Trolox from the pores of RSS-140. The biocompatibility and nontoxicity of Trolox subset of Azo@RSS-140, together with the absolute control over the nanovalve opening, were established to yield a system that safely and slowly releases Trolox for longer-lasting antioxidant efficacy. As the field of supramolecular chemistry is rich with similar systems and many such systems can be used as building blocks to construct HOFs or other extended framework materials, we envision the molecular nanovalve concept to be applied widely for controllably delivering molecular cargo for diverse applications.