Affinity Targeting of Therapeutic Proteins to the Bone Surface-Local Delivery of Sclerostin-Neutralizing Antibody Enhances Efficacy.

Boya Zhang,William Benton Swanson,Margaret Durdan, Heather N. Livingston,Michaela Dodd,Sachith M. Vidanapathirana,Alec Desai,Lindsey Douglas,Yuji Mishina,Megan Weivoda,Colin F. Greineder

Journal of Bone and Mineral Research（2024）

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Key words

osteoporosis,diseases and disorders of/related to bone,preclinical studies,animal models,wnt/beta-catenin/lrps,cell/tissue signaling-paracrine pathways,therapeutics,anabolics,therapeutics

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