Proteome Characterization of XPC-deficient Melanocytes Generated by CRISPR-Cas9 Technology Reveals Alteration in the Expression of Several Hundred Proteins

Muriel Cario, Julie Scalia,Walid Mahfouf,Elodie Muzotte,Vincent Michaud,Claudio Plaisant,Jean-William Dupuy,Thierry Douki,Fanny Morice-Picard,Jérôme Rambert, Eric Perrier,Sandra Trompezinski,Hamid-Reza Rezvani

Journal of Dermatological Science（2024）

引用 0|浏览21

暂无评分

摘要

•CRISPR-Cas9 is a valuable tool for creating XPC-deficient primary melanocytes •XPC-deficient primary melanocytes (©-XPC-Mel) are hypersensitive to UV •©-XPC-Mel pave the way for studying the effects of NER on melanocyte biology •About 500 proteins are differentially expressed in ©-XPC-Mel compared to ©-Ctrl-Mel •The balance between pro- and anti-inflammatory signals is disturbed in ©-XPC-Mel

查看译文

关键词

melanocyte,xeroderma pigmentosum,nucleotide excision repair,modelling,immune response,CRISPR-Cas9,proteomics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要