Guanidinium-terminated Gold Nanoparticles for Protein Delivery to the Cell Nucleus

Guanidinium-terminated 1.7 nm gold has been designed using thiolated-arginine as a capping ligand and used for cell nucleus delivery of proteins within 5 min; similar types of nanocarriers can be designed for sub-cellular targeting/delivery of macromolecular drugs. Proteins are delivered to the cell nucleus within 5 minutes via direct membrane penetration using guanidinium-terminated 1.7 nm gold as a delivery carrier.