Chrome Extension
WeChat Mini Program
Use on ChatGLM

Device-detected Atrial Sensing Amplitudes As a Marker of Increased Risk for New Onset and Progression of Atrial High-Rate Episodes

Heart Rhythm(2024)

Policlin St Orsola Malpighi | Humanitas Gavazzeni | Osped Martini & Maria Vittoria | Spedali Civil Brescia | Fdn IRCCS San Gerardo dei Tintori | Osped Misericordia | Osped Infermi | ASST Grande Osped Metropolitano Niguarda | Arcispedale Santa Maria Nuova | Osped Santa Chiara | Osped Carlo Poma | Osped Cirie | Osped Circolo Varese | Azienda OU Policlin G Rodolico San Marco | Azienda Osped Univ Integrata Verona | Univ Vanvitelli AO Monaldi | Osped Bolognini | Azienda Osped Univ Parma | Univ Bari Aldo Moro | Osped Bentivoglio | Osped Apuane | Clin Montevergine | Osped Santa Maria Annunziata | Osped Pugliese Ciaccio | Osped Santa Maria Nuova | Osped Santa Maria della Pieta | Biotronik Italia Spa | Maria Cecilia Hosp

Cited 0|Views28
Abstract
BackgroundAtrial high-rate episodes (AHRE) are frequent in patients with cardiac implantable electronic devices. A decrease in device-detected P-wave amplitude may be an indicator of periods of increased risk of AHRE.ObjectiveTo assess the association between P-wave amplitude and AHRE incidence.MethodsRemote monitoring data from 2,579 patients with no history of atrial fibrillation (23% pacemakers, 77% implantable cardioverter-defibrillators [ICDs] of which 40% providing cardiac resynchronization therapy [CRT]) were used to calculate the mean P-wave amplitude during 1 month after implantation. The association with AHRE incidence according to four strata of daily burden duration (≥15 minutes, ≥6 hours, ≥24 hours, ≥7 days) was investigated by adjusting the hazard ratio with the CHA2DS2-VASc score.ResultsThe adjusted hazard ratio (HR) for 1-mV lower mean P-wave amplitude during the first month increased from 1.10 (95% confidence interval [CI], 1.05-1.15; p<0.001) to 1.18 (CI, 1.09-1.28; p<0.001) with AHRE duration strata from ≥15 minutes to ≥7 days independently of the CHA2DS2-VASc score. Among 871 patients with AHREs, those with 1-month P-wave amplitude <2.45 mV had an adjusted HR of 1.51 (CI, 1.19-1.91; p=0.001) for progression from ≥15 minutes to ≥7 days AHREs compared to those with 1-month P-wave amplitude ≥2.45 mV. Device-detected P-wave amplitudes decreased linearly during the one year before the first AHRE by 7.3% (CI, 5.1%-9.5%, p<0.001 versus patients without AHRE).ConclusionDevice-detected P-wave amplitudes lower than 2.45 mV were associated with an increased risk of AHRE onset and progression to persistent forms of AHRE independently of the patient’s risk profile.
More
Translated text
Key words
Atrial fi brillation,Subclinical AF,AHRE,P wave,Device-detected AF
求助PDF
上传PDF
Bibtex
AI Read Science
AI Summary
AI Summary is the key point extracted automatically understanding the full text of the paper, including the background, methods, results, conclusions, icons and other key content, so that you can get the outline of the paper at a glance.
Example
Background
Key content
Introduction
Methods
Results
Related work
Fund
Key content
  • Pretraining has recently greatly promoted the development of natural language processing (NLP)
  • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
  • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
  • The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
  • Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance
Upload PDF to Generate Summary
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Related Papers
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn
Chat Paper

要点】:研究显示,心脏植入设备检测到的P波振幅降低与心房高频事件(AHRE)的新发和进展风险增加相关,独立于患者的风险评分。

方法】:通过分析2579名无房颤病史患者的远程监测数据,计算植入后一个月内的平均P波振幅,并探讨其与不同持续时间AHRE发生率的关联。

实验】:使用植入的心脏电子设备(包括23%的起搏器和77%的心脏复律除颤器,其中40%提供心脏同步化治疗)进行远程监测,数据集未具体提及名称。结果显示,第一月平均P波振幅每降低1毫伏,AHRE发生的调整危险比从≥15分钟持续时间的1.10增加到≥7天持续时间的1.18。