Affinity Fine-Tuning Anti-Caix CAR-T Cells Mitigate On-Target Off-Tumor Side Effects
Yufei Wang,Alicia Buck,Brandon Piel,Luann Zerefa,Nithyassree Murugan,Christian D. Coherd,Andras G. Miklosi, Haraman Johal, Ricardo Nunes Bastos, Kun Huang,Miriam Ficial,Yasmin Nabil Laimon,Sabina Signoretti,Zhou Zhong,Song-My Hoang,Gabriella M. Kastrunes,Marion Grimaud,Atef Fayed, Hsien-Chi Yuan,Quang-De Nguyen,Tran Thai,Elena V. Ivanova,Cloud P. Paweletz,Ming-Ru Wu, Toni K. Choueiri,Jon O. Wee,Gordon J. Freeman,David A. Barbie,Wayne A. Marasco MOLECULAR CANCER（2024）
关键词
Chimeric antigen receptor (CAR) T,Affinity/avidity fine-tuned,Clear cell renal cell carcinoma (ccRCC),Carbonic anhydrase IX (CAIX),Direct stochastic optical reconstruction microscopy (dSTORM),On-target off-tumor (OTOT) toxicity
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