TRPV1 Analgesics Disturb Core Body Temperature Via a Biased Allosteric Mechanism Involving Conformations Distinct from That for Nociception

Yi-Zhe Huang, Jing-Xian Ma, Yu-Jing Bian, Qin-Ru Bai, Yu-Hao Gao, Shu-Ke Di,Yun-Tao Lei, Hui Yang,Xiao-Na Yang, Chang-Yan Shao,Wen -Hui Wang,Peng Cao,Chang -Zhu Li,Michael X. Zhu,Meng -Yang Sun,Ye Yu

NEURON（2024）

Cited 2|Views43

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Key words

TRPV1 analgesics,core body temperature,biased allosteric mechanism,nociception,hyperthermia,S4-S5 linker domain,TRP-box domain

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