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    • Supplemental Figure 4 from Impact of Tumor-intrinsic Molecular Features on Survival and Acquired Tyrosine Kinase Inhibitor Resistance in ALK-positive NSCLC

    crossref（2024）

    Cited 0|Views43
    Abstract
    Clonal and non-clonal ALK resistance mutations across patients with multiple resistance mutations. Each ALK mutation is plotted by sample and colored by putative clonal classification based on the maximum difference between resistance mutation mutant allele frequencies (MAFs). Inset table provides the clonal and non-clonal patient counts for those with v1/v3 variant types. Chi-squared statistic indicates there is no significant association with resistance clonality and fusion type.
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    ALK Inhibitors,Biomarker Analysis,Survival Analysis
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
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    【要点】：本论文探讨了ALK阳性非小细胞肺癌（NSCLC）患者中，肿瘤内在分子特征对生存和获得性酪氨酸激酶抑制剂（TKI）耐药性的影响，揭示了克隆性和非克隆性ALK耐药突变的存在。
    

    【方法】：通过比较不同样本中耐药突变变异等位基因频率（MAFs）的最大差异，对ALK突变进行克隆性分类，并分析了克隆性与融合类型的关系。
    

    【实验】：本文通过插图4展示了具有多个耐药突变的患者中克隆性和非克隆性ALK抵抗突变，附件表格提供了v1/v3变异类型的克隆性和非克隆性患者数量。卡方统计显示，耐药性克隆性与融合类型之间没有显著关联。