Establishment and Characterization of NCC-ASPS2-C1: a Novel Patient-Derived Cell Line of Alveolar Soft Part Sarcoma
Human cell(2024)
摘要
Alveolar soft part sarcoma (ASPS) is a rare mesenchymal tumor characterized by rearrangement of the ASPSCR1 and TFE3 genes and a histologically distinctive pseudoalveolar pattern. ASPS progresses slowly, but is prone to late metastasis. As ASPS is refractory to conventional chemotherapy, the only curative treatment is complete surgical resection. The prognosis of advanced and metastatic cases is poor, highlighting the need for preclinical research to develop appropriate treatment options. However, ASPS is extremely rare, accounting for < 1
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关键词
Alveolar soft part sarcoma,Patient-derived cancer model,Patient-derived cell lines,Fusion gene,NCC-ASPS2-C1
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