Precise Engineering of the Biomolecular Corona to Accelerate the Clinical Translation of Lipid Nanoparticles
Trends in biotechnology(2024)
摘要
Understanding and meticulously engineering the biomolecular corona on the surface of lipid nanoparticles can accelerate their successful clinical applications beyond mRNA vaccines. We outline the major hurdles of clinical development faced by lipid nanoparticles and discuss how considering and modifying the biomolecular corona could mitigate these challenges.
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关键词
protein corona,biomolecular corona,lipid nanoparticles,clinical translation,corona engineering
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