Synthesis of Easily-Modified and Useful Dibenzo-[B,d]azepines by Palladium(ii)-Catalyzed Cyclization/addition with a Green Solvent.

A novel strategy in which palladium(ii)-catalyzed tandem cyclization is used to obtain N-heterocyclic architectures containing a seven-membered ring has been developed and used to synthesize a series of derivatives. The reaction uses an eco-friendly mixed solvent (water : EtOH = 2 : 1) instead of DMSO and maintains a high yield (91%). Its potential application value and reaction mechanism have also been explored.