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Circulating immune cells and multiple myeloma: A mendelian randomization study

crossref(2024)

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摘要
Abstract Objective Multiple myeloma (MM) is a malignant proliferative disease of plasma cells. Although plasma cells play an important role in this process, their relationship with other circulating immune cells has not been systematically investigated. Methods The single nucleotide polymorphism (SNP) data of 721 circulating immune cells and MM were obtained from GWAS summary data. After meeting the three assumptions of mendelian randomization (MR), we used inverse-variance weighted (IVW) as the main method to evaluate the causal association between the two. For positive results, we used multivariable mendelian randomization (MVMR) for adjustion and performed reverse MR analysis to assess the stability of the results. Results A total of 3 circulating immune cells are causally related to MM. Among them, Naive CD8 + T cell %T cell (IVW OR: 1.00123, 95%CI: 1.00015–1.00231, P value: 0.02518), Natural Killer T Absolute Count (IVW OR: 1.00062, 95%CI: 1.00006-1.00118, P value :0.03075) was a risk factor for MM, and CD28 + CD45RA + CD8 + T cell %T cell (IVW OR: 0.99993, 95%CI: 0.99987-1.00000, P value: 0.03549) was a protective factor for MM. This result remained stable in the MVMR analysis. Among them, Naive CD8 + T cell %T cell (IVW OR: 1.00200, 95%CI: 1.00058–1.00343, P value: 0.00586), Natural Killer T Absolute Count (IVW OR: 1.00051, 95%CI: 1.00002-1.00101, P value : 0.04225) was a risk factor for MM, and CD28 + CD45RA + CD8 + T cell %T cell (IVW OR: 0.99913, 95%CI: 0.99860–0.99967, P value: 0.00158) was a protective factor for MM. No reverse causal relationship was found between MM and these 3 circulating immune cells. Conclusions There was a causal association between 3 circulating immune cells and MM, which may provide a new strategy for the prevention and treatment of MM. Further randomized controlled studies are still needed to further elucidate their relationship.
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