IDH Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation

Lih En Hong,Mihir D Wechalekar,Monika Kutyna,Annabelle Small, Kelly Lim,Chloe Thompson-Peach, Joule J Li,Rakchha Chhetri,Hamish S Scott,Anna Brown, Christopher N Hahn,David T Yeung, Salvia Sajid,Nirmal Robinson,Ranjeny Thomas,Susan Branford, Richard J D’Andrea,Saumya E Samaraweera,Mrinal Patnaik,Susanna Proudman

Blood（2024）

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摘要

High prevalence of IDH-mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity and pro-inflammatory microenvironment, suggests causative association between IDH-mutations and seronegative RA. Our findings merit investigation of IDH-inhibitors as therapeutics for seronegative IDH-mutated RA.

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关键词

MDS,AIRD,t-MN,autoimmune rheumatic diseases

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