A Chimeric Porcine Reproductive and Respiratory Syndrome Virus 1 Strain Containing Synthetic ORF2-6 Genes Can Trigger T Follicular Helper Cell and Heterologous Neutralizing Antibody Responses and Confer Enhanced Cross-Protection

Shubin Li,Ming Qiu,Shuai Li,Chen Li,Hong Lin,Yuejia Qiu,Wenhao Qi,Binghui Feng, Meng Cui, Shuai Yang,Wanglong Zheng,Shaobin Shang,Kegong Tian,Jianzhong Zhu,Yu Lu,Nanhua Chen

VETERINARY RESEARCH（2024）

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porcine reproductive and respiratory syndrome virus 1 (PRRSV1),ORF2-6 chimeric virus,cross-protection,T follicular helper (Tfh) cells,neutralizing antibodies (nAbs),IFNγ-secreting cells

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