Prevalence of Atopic Disorders among Pediatric Patients with Pulmonary and Disseminated Coccidioidomycosis
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY(2024)
Abstract
Type 2 inflammatory responses are associated with worse prognosis in coccidioidomycosis. It is unclear whether patients with preexisting type 2 inflammation and atopic disorders are predisposed to disseminated coccidioidomycosis. A retrospective analysis of pediatric patients with disseminated coccidioidomycosis revealed no significant difference in the history of atopic disorders or eosinophilia as compared to those with isolated pulmonary disease. Tissue-specific type 2 responses may still play a role in coccidioidomycosis immune dysregulation, and further investigation is needed.
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Key words
coccidiomycosis,pediatrics,type 2 inflammation
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