Exploration of Key Molecules for Diosgenin-Induced Axonal Regeneration in the Brain.

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by deposition of Aβ. Our therapeutic strategy for AD is to regenerate neural circuits in the brain to recover memory function. We previously found diosgenin as a candidate drug for regenerating axons in the brain and improving memory impairment in AD model (5XFAD) mouse. In addition, diosgenin-driven axonal regeneration is mediated by changes in expression levels of several proteins (e.g. SPARC, Galectin-1) in neurons. In this study, we aimed to explore key candidate molecules that regulate the expression of these axonal regeneration-related proteins and clarify their contributions to axonal regeneration and memory recovery.