Activity Dependent Reduction of Synaptic Molecules in Hippocampal Mossy Fiber Terminals after Novel Context Exploration

In the dentate gyrus (DG), the novel context (NC) exploration activates a sparse population of granule cells (GCs). Stimulated GCs reshape computations in the hippocampal neural circuitry by modifying their synaptic plasticity, particularly at mossy fiber terminals (MFTs). Nevertheless, it remains elusive what molecular changes occur at MFTs of GCs which are active during the NC exposure.