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Microglia Are Not Necessary for Maintenance of Blood-Brain Barrier Properties in Health, but PLX5622 Alters Brain Endothelial Cholesterol Metabolism

Caterina P. Profaci, Sean S. Harvey, Kaja Bajc, Tony Z. Zhang,Danielle A. Jeffrey, Alexander Z. Zhang,Kelsey M. Nemec,Hayk Davtyan,Carleigh A. O'Brien,Gabriel L. Mckinsey,Aaron Longworth,Timothy P. Mcmullen,Joia K. Capocchi, Jessica G. Gonzalez,Devon A. Lawson,Thomas D. Arnold,Dimitrios Davalos,Mathew Blurton-Jones,Fabrice Dabertrand,F. Chris Bennett,Richard Daneman

Neuron（2024）

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关键词
blood-brain barrier,microglia,cholesterol,LDLR,CSF1R,PLX5622,endothelial cells,vasculature,genetic microglial depletion,off-target effects
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