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Methods to Improve Antibacterial Properties of PEEK: A Review.

Biomedical Materials(2024)

Middle East Tech Univ

Cited 0|Views10
Abstract
As a thermoplastic and bioinert polymer, polyether ether ketone (PEEK) serves as spine implants, femoral stems, cranial implants, and joint arthroplasty implants due to its mechanical properties resembling the cortical bone, chemical stability, and radiolucency. Although there are standards and antibiotic treatments for infection control during and after surgery, the infection risk is lowered but can not be eliminated. The antibacterial properties of PEEK implants should be improved to provide better infection control. This review includes the strategies for enhancing the antibacterial properties of PEEK in four categories: immobilization of functional materials and functional groups, forming nanocomposites, changing surface topography, and coating with antibacterial material. The measuring methods of antibacterial properties of the current studies of PEEK are explained in detail under quantitative, qualitative, andin vivomethods. The mechanisms of bacterial inhibition by reactive oxygen species generation, contact killing, trap killing, and limited bacterial adhesion on hydrophobic surfaces are explained with corresponding antibacterial compounds or techniques. The prospective analysis of the current studies is done, and dual systems combining osteogenic and antibacterial agents immobilized on the surface of PEEK are found the promising solution for a better implant design.
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PEEK,antibacterial rate,biomedical applications,surface modifications
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要点】:本文综述了改善聚醚醚酮(PEEK)抗菌性的策略,并分析了相关测量方法及抗菌机制,指出结合成骨和抗菌剂的双系统是提升植入物设计的潜在解决方案。

方法】:文章从固定功能材料和功能团、形成纳米复合材料、改变表面拓扑结构、以及涂覆抗菌材料四个方面综述了增强PEEK抗菌性的方法。

实验】:本文详细解释了现有研究中测量PEEK抗菌性的定量、定性和体内方法,并探讨了通过生成活性氧、接触杀灭、陷阱杀灭和限制细菌在疏水表面粘附的细菌抑制机制;但没有提供具体实验细节和数据集名称。