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A Novel Heterozygous Variant in AICDA Impairs Ig Class Switching and Somatic Hypermutation in Human B Cells and is Associated with Autosomal Dominant HIGM2 Syndrome.

Erika Della Mina,Katherine J. L. Jackson, Alexander J. I. Crawford,Megan L. Faulks,Karrnan Pathmanandavel, Nicolino Acquarola,Michael O’Sullivan,Tessa Kerre,Leslie Naesens,Karlien Claes,Christopher C. Goodnow,Filomeen Haerynck,Sven Kracker,Isabelle Meyts,Lloyd J. D’Orsogna,Cindy S. Ma,Stuart G. Tangye

JOURNAL OF CLINICAL IMMUNOLOGY（2024）

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Key words
HIGM2,AICDA,Ig class switching,Somatic hypermutation,Human B cells
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