2,3-Diaminopyridine As a Platform for Designing Structurally Unique Nonpeptide Bradykinin B1 Receptor Antagonists

DM Feng,JM Wai,SD Kuduk,C Ng,KL Murphy,RW Ransom,D Reiss, RSL Chang,CM Harrell,T MacNeil,C Tang,T Prueksaritanont, RM Freidinger,DJ Pettibone,MG Bock

Bioorganic & medicinal chemistry letters（2005）

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摘要

A novel class of 2,3-diaminopyridine bradykinin 131 receptor antagonists is disclosed. Structure-activity relationship studies (SARs) that led to compounds with significantly improved potency and pharmacokinetic properties relative to the lead compound are described. (c) 2005 Elsevier Ltd. All rights reserved.

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关键词

Bradykinin B1,Receptor,Antagonists,2,3-Diaminopyridine

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