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Discovery and Optimization of Spirocyclic Lactams That Inhibit Acyl-Acp Thioesterase

Elisabeth Asmus,David M. Barber,Guido Bojack,Birgit Bollenbach-Wahl,Ronald W. Brown,Uwe Doeller,Joerg Freigang,Elmar Gatzweiler,Rahel Getachew,Ines Heinemann,Sabine Hohmann, Kwang-Yoon Ko,Bernd Laber,Gudrun Lange,Rebecca L. Mattison,Klemens Minn,Thomas Mueller, Thomas Petry,Anna M. Reingruber,Dirk Schmutzler, Andrea Svejda,Jens Frackenpohl

PEST MANAGEMENT SCIENCE（2024）

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Key words
herbicide,resistance,acyl-ACP thioesterase,spirocyclic lactams,structure-activity relationship,bioisosteres
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