Mutant p53 Gain-of-Function in the Spotlight: Are We Suffering a GOF Delusion?
Cancer discovery(2024)
摘要
Mutant p53 proteins are often highly expressed in human cancers and have been thought to have oncogenic driver gain-of-function (GOF) properties. Wang and colleagues show, surprisingly, that this is not the case because removing the TP53-mutant gene from human and mouse cancer cells using CRISPR technology has no effect on cancer cell growth in vitro or in vivo.
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