Time to Sputum Culture Conversion and Its Associated Factors among Drug-Resistant Tuberculosis Patients: a Systematic Review and Meta-Analysis.

Objective We aimed to evaluate the sputum culture conversion time of DR-TB patients and its related factors. Methods PubMed, The Cochrane Library, Embase, CINAHL, Web of Science, CNKI, Wan Fang, CBM and VIP databases were electronically searched to collect studies on sputum culture conversion time in patients with DR-TB. Meta-analysis was performed by using the R 4.3.0 version and Stata 16 software. Results A total of 45 studies involving 17373 patients were included. Meta-analysis results showed that the pooled median time to sputum culture conversion was 68.57 days (IQR 61.01,76.12). The median time of sputum culture conversion in patients with drug-resistant tuberculosis was different in different WHO regions, countries with different levels of development and different treatment schemes. And female ( aHR = 0.59,95% CI: s 0.46,0.76), alcohol history ( aHR = 0.70,95% CI: 0.50,0.98), smoking history (a HR = 0.58,95% CI: 0.38,0.88), history of SLD use ( aHR = 0.64,95% CI: 0.47,0.87), BMI < 18.5 kg/m 2 ( aHR = 0.69,95% CI: 0.60,0.80), lung cavity ( aHR = 0.70,95% CI: 0.52,0.94), sputum smear grading at baseline (Positive) ( aHR = 0.56,95% CI: 0.36,0.87), (grade 1 + ) ( aHR = 0.87,95% CI: 0.77,0.99), (grade 2 + ) ( aHR = 0.81,95% CI: 0.69,0.95), (grade 3 + ) ( aHR = 0.71,95% CI: 0.61,0.84) were the related factor of sputum culture conversion time in patients with DR-TB. Conclusion Patients with DR-TB in Europe or countries with high level of economic development have earlier sputum culture conversion, and the application of bedaquiline can make patients have shorter sputum culture conversion time. Female, alcohol history, smoking history, history of SLD use, BMI < 18.5 kg/m 2 , lung cavity, sputum smear grading at baseline (Positive, grade 1 + , grade 2 + , grade 3 + ) may be risk factors for longer sputum culture conversion time. This systematic review has been registered in PROSPERO, the registration number is CRD42023438746.