Antibody-Drug Conjugates: Advancing from magic bullet to biological missile.
Clinical cancer research : an official journal of the American Association for Cancer Research（2024）
摘要
Precision drug development is focusing on targeting tumor cell surface proteins for therapeutic delivery, maximizing biomarker identified on-target damage to the tumor while minimizing toxicity. A recent article demonstrated high expression of B7-H4 antigen on resistant ovarian cancer cells and described preclinical activity of B7-H4-directed antibody-drug conjugate.
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