07 - GENDER-SPECIFIC DIFFERENCES AT BOTH EXTREME ENDS OF THE LDL CHOLESTEROL DISTRIBUTION CURVE

No differences detected in Lp(a) concentration in patients grouped according to their Dutch Lipid Clinic Network (DLCN) Criteria for FH clinical diagnosis, n=140.p=0.285;Test Kruskal-Wallis Lp(a) in patients genotyped for FH (NGS for LDLR, APOB, PCSK9, APOE and LDLRap1),(n=95) No differences were observed between patients with Positive or Negative genetic study.p=0.214;U-Mann WhitneyTest Conclusions: a-In a subgroup of our hypercholesterolemic cohort, we verified an independence between Lp(a) and LDL-C levels.b-Lp(a) did not show associations with FH clinical diagnosis (DLCN) nor with FH genetic testing results.c-However, it must be highlighted that the coexistence of increased LDL-C and Lp(a) levels impair the severity and prognosis of CVD d-Testing for elevated Lp(a) during cascade screening for FH is effective in identifying relatives with high Lp(a) and increased risk ASCVD (SAFEHEART, Mata P et al, 2019, 73,9:1029)