(ARTO Trial-Nct03449719): Role of Local Treatment after Progression in Patients with Castrate-Resistant Prostate Cancer Undergoing First-Line Abiraterone Treatment.

130 Background: ARTO (NCT03449719) is a multicentre, randomized phase II trial testing the benefit of concomitant stereotactic body radiation therapy (SBRT) and abiraterone acetate (AA)+ prednisone administration in oligometastatic Castrate Resistant Prostate Cancer (CRPC) patients. Results already showed significant benefit in terms of biochemical response and Progression Free Survival (PFS) in the experimental arm. To explore role of local treatment throughout the whole clinical history of these patients, here is reported a subgroup analysis focusing on impact of treatment (SBRT vs second line systemic therapy) after progression. Methods: Patients affected by oligometastatic CRPC (更多