Changes of Serum Markers Hepatitis B Virus Infection in Gansu Province

Objective To understand changes of serum markers of Hepatitis B infection in Gansu Province.Method Sero-epidemiological survey data of hepatitis B in 1980,1992 and 2006 in Gansu province were analyzed comparatively.Result HBsAg positive rate decreased from 7.52% to 4.39% in Gansu Province.HBsAg positive rate of children under 10 years old decreased to 1.66%,which decreased by more than77% compared with that of 1980 and 1992.HBsAg positive rate of the rural areas was higher than city,but decline of HBsAg positive rate in urban was larger than that in rural areas.AntiHBs rate significantly increased from 3.11% to 49.48%,and Anti-HBs rate of 1992 increased with age rising,while Anti-HBs rate of 2006 fell with age rising,and Anti-HBs rate of children under 10 years old was the highest.HBV infection and anti-HBc positive rate increased gradually with age rising,but all infection rate and positive rate of 2006 was significantly lower than that in 1992.Conclusion Hepatitis B infection rate decreased significantly in Gansu Province,which means that Hepatitis B vaccine has achieved good results,especially the effects of immunization strategies for children are more significant.