Expression and Significance of OATP-B,D Protein and Mrna in Lung Cancer

Objective To investigate the expression and clinical significance of organic anion transporting polypeptide(OATP)-B,D mRNA and protein in lung cancer.Methods The expressions of OATP-B and OATP-D mRNA were detected in 40 cases of lung cancer and 10 cases normal lung tissues by SYBRGreen Quantitative Real-time PCR,as well as the expressions of OATP-B and OATP-D were available by immunohistochemistry analysis.Results The expressions of OATP-B and OATP-D mRNA were all significantly up-regulated in different pathological category lung neoplasms compared to normal lung tissues.There was also a significant difference in the expressions of OATP-B and OATP-D mRNA between lymph metastasis lung neoplasms and those without lymph metastasis,P0.05.Immunohistochemistry analysis showed a higher expression of OATP-B and OATP-D protein in lung cancers than normal lung tissues,as well as in lung cancers with lymph metastasis compared to those without lymph metastasis(P0.05).Conclusion The expression of OATP-B and OATP-D mRNA and protein raise in lung cancer.Both of them are associated with lymph metastasis.