Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice (small 49/2023)

Danielle J. Beetler,Katelyn A. Bruno, M C Watkins, Vivian Xu, Isha Chekuri, Presley Giresi, Damian N. Di Florio,Emily R. Whelan, Brandy Edenfield,Sierra A. Walker,Andrea Carolina Morales-Lara,Anneliese R. Hill,Angita Jain, Matthew E. Auda, Logan P. Macomb, Kathryn A. Shapiro, Kevin C. Keegan,Joy Wolfram,Atta Behfar,Paul G. Stalboerger,André Terzic,Houssam Farres,Leslie T. Cooper,DeLisa Fairweather

Small（2023）

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摘要

Regenerative Medicine Extracellular vesicles from healthy human platelets globally control inflammation in the hearts of mice with viral myocarditis by regulating the innate immune response with their heterogenous functional contents. This immunomodulation in part comes from anti-inflammatory microRNAs and prevents cardiac dysfunction during peak acute myocarditis. The therapeutic tested in article number 2303317 by DeLisa Fairweather and co-workers offers a novel and translatable option for inflammatory cardiovascular diseases.

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