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Chimeric Antigen Receptor-Induced Antigen Loss Protects Cd5.Cart Cells from Fratricide Without Compromising On-Target Cytotoxicity

Royce Ma,Mae Woods, Phillip Burkhardt, Noah Crooks,Dayenne G. van Leeuwen,Daniil Shmidt,Jacob Couturier, Alexandre Chaumette,Divya Popat,LaQuisa C. Hill,Rayne H. Rouce,Sachin Thakkar,Aaron F. Orozco,Alexandre F. Carisey,Malcolm K. Brenner,Maksim Mamonkin

CELL REPORTS MEDICINE（2024）

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关键词
chimeric antigen receptor,T cell fratricide,CD5,T cell malignancies,off-tumor toxicity,clinical trials,CAR,fratricide
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