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    • 2609. Comprehensive Cost Assessment among Families with Children Younger Than 2 Years-of-age Hospitalized with RSV Infection

    Krow Ampofo, Evan G Heller,Lazarus Adua, Abbey Lovebridge, Kaleb Miller, Kathrine Lindsey Werdan,Per H Gesteland,Madelyn Ruggieri,Lyn Finelli,Yoonyoung Choi

    Open Forum Infectious Diseases（2023）SCI 3区SCI 4区

    University of Utah | University of Utah School of Medicine | Merck & Co. | Merck&Co. | Merck

    Cited 0|Views3
    Abstract
    Abstract Background Respiratory Syncytial Virus (RSV) is a major cause of childhood lower respiratory tract infection (LRTI) in the U.S. While RSV hospital (direct) cost is well described, the impact on work productivity and additional RSV-related (indirect) costs are not known. We describe direct and indirect cost occurring to a family before, during, and after child’s RSV hospitalization. Methods We prospectively identified children < 2 years of age hospitalized with laboratory-confirmed RSV LRTI at Primary Children’s and Riverton Hospitals, Salt Lake City, UT, from 12/2019 to 5/2022. RSV hospitalization-related cost consisted of 1) Hospital cost, 2) indirect costs occurring between a week before admission and up to 2 weeks post discharge, and 3) productivity loss of caregivers during child’s admission. We abstracted hospital financial data and surveyed caregivers using a questionnaire developed for the study, along with the Work Productivity and Activity Impairment Questionnaire: Child’s Hospitalization for Respiratory Illness instrument. Results During the study period, 684 children < 2 years were hospitalized with RSV LRTI with a median length of stay 1.8 days (IQR 1-3.1 days) and mean hospital cost of 2023 USD $11703 (std: $25292). Of the 146 (21%) caregivers who participated in the survey, 140/146 (96%) reported at least one caregiver is currently employed and 123/146 (79%) were female. One week prior to admission, 109/146 (75%) visited a healthcare facility and spent a mean of $58 (std $129) out of pocket cost for the visits, medication, and additional childcare. Before RSV hospitalization, 81/140 (58%) employed caregivers lost work hours (hrs) (mean 15 hrs; std 15 hrs) and had an average productivity impairment score of 4.4 out of 10 (std 3.6) (10=worst impairment). After discharge, 68/146 (47%) children required a healthcare visit, 67/140 (48%) caregivers lost work hrs (mean 27 hrs; std 32 hrs) and spent a mean of $93 (std $206) out of pocket cost. (Table) Conclusion The hospitalization of children < 2 years with RSV LRTI is associated with significant costs during and after hospitalization. These costs include caregivers’ loss of work hours and additional out-of-pocket costs. Our data support the need for RSV vaccines and immunoprophylaxis to prevent RSV hospitalization. Disclosures Krow Ampofo, MBChB, Merck: Advisor/Consultant|Merck: Grant/Research Support Lyn Finelli, DrPH, MS, Merck&Co: Stocks/Bonds Yoonyoung Choi, PhD, MS, RPh, Merck: Employed|Merck: Stocks/Bonds
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    Respiratory Syncytial Virus
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    【要点】：本研究详细评估了小于2岁儿童因呼吸道合胞病毒（RSV）感染住院治疗期间及其前后家庭所承担的直接和间接成本，强调了RSV疫苗和免疫预防的必要性。
    

    【方法】：通过前瞻性识别2019年12月至2022年5月在犹他州盐湖城的Primary Children’s和Riverton医院住院治疗的684名小于2岁的RSV下呼吸道感染（LRTI）儿童，利用医院财务数据和针对本研究开发的问卷及工作生产力和活动障碍问卷（Child’s Hospitalization for Respiratory Illness）来收集数据。
    

    【实验】：研究期间共收集了684名儿童的住院数据，住院中位时长为1.8天，平均住院费用为11703美元。146名参与调查的看护者中，96%表示至少有一名看护人目前就业，79%为女性。结果显示，住院前一周，75%的儿童访问了医疗机构，平均自付费用为58美元；住院前，58%的就业看护者损失了工作时间，平均生产力损失评分为4.4（满分10）。出院后，47%的儿童需要再次访问医疗机构，48%的看护者损失了工作时间，平均自付费用为93美元。