336MO Genetic Landscape and Prognostic Value of IRF4 Alterations in Diffuse Large B Cell Lymphoma Patients

Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell non-Hodgkin lymphoma with high heterogeneity. The prognosis of patients with IRF4 alterations in various hematologic malignancies showed an opposite prognosis. After removing patients with poor prognostic factors, this study aims to investigate the relationship between the DLBCL genetic landscape and the efficacy of first-line R-CHOP or R-CHOP-like regimens. Further explore the prognostic significance of IRF4 alterations in DLBCL patients.