Exploiting High-Energy Hydration Sites for the Discovery of Potent Peptide Aldehyde Inhibitors of the SARS-CoV-2 Main Protease with Cellular Antiviral Activity

Daniel W. Carney,Abba E. Leffler,Jeffrey A. Bell, Asela S. Chandrasinghe, Cecilia Cheng,Edcon Chang, Adam Dornford,Douglas R. Dougan,Leah L. Frye, Mary E. Grimes, Tim Knehans,Jennifer L. Knight,Mallareddy Komandla,Weston Lane,Hubert Li, Sophia R. Newman, Katalin Phimister, Kumar S. Saikatendu, Hercules Silverstein, Shaghayegh Vafaei

BIOORGANIC & MEDICINAL CHEMISTRY（2024）

引用 0|浏览5

暂无评分

关键词

COVID-19,SARS-CoV-2,Main protease,Mpro,WaterMap,Free -energy perturbation,Peptide aldehyde,Peptidomimetic,Protease inhibitor

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要