Discovery and Optimization of Dihydropteridone Derivatives As Novel PLK1 and BRD4 Dual Inhibitor for the Treatment of Cancer
BIOORGANIC & MEDICINAL CHEMISTRY（2024）
Key words
PLK1/BRD4 dual inhibitors,Dihydropteridone derivatives,Isoindolin-1-one or isoindoline moieties,Anticancer activity,Structure activity relationship
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