The Mechanism of Ceftazidime and Cefiderocol Hydrolysis by D179Y Variants of KPC Carbapenemases is Similar and Involves the Formation of a Long-Lived Covalent Intermediate.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY（2024）
关键词
KPC-31 beta-lactamase,KPC-33 beta-lactamase,antibiotic resistance,beta-lactamase,cross-resistance,enzyme variants,transient kinetics
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